Date of Award
2020
Document Type
Thesis
Degree Name
Bachelor of Science
Department
Biochemistry & Molecular Biol.
First Advisor
Dr. John Gupton
Abstract
Pyrroles and pyrazoles are privileged structures which provide a molecular framework found in many different classes of bioactive compounds, thus rendering their syntheses useful in pharmaceutical drug development. Additionally, being able to selectively create these molecules with interesting substituents allows for different pharmacological and biological activities, such as antitumor and antibiotic effects. Our group has used β-chloroenals in the application of many different unique synthetic strategies in the past, and here I show that chloroenals can be used to synthesize novel 1,2,5 trisubstituted pyrroles as well as 1,5 di- and 1,4,5 trisubstituted pyrazoles in fewer steps and with milder conditions than previously reported.
Recommended Citation
Siewert, Julia Powell, "Application of β-chloroenals: one-pot syntheses to create highly variable, functional, and biologically interesting molecules" (2020). Honors Theses. 1514.
https://scholarship.richmond.edu/honors-theses/1514