Date of Award
Bachelor of Science
Biochemistry & Molecular Biol.
Dr. Kristine A. Nolin
Calcium(II) complexes have be shown to be successful catalysts for nitrone reactions. The addition of n-‐methyl and n-‐phenyl nitrones to donor-‐acceptor cyclopropanes was achieved with calcium triflate (Ca(OTf). Differentially substituted tetrahydro-‐1,2-‐oxazines were synthesized in good to excellent yields. Calcium triflate was also found to catalyze the addition of silyl enol ethers to n-‐phenyl nitrones along the Mukaiyama-‐Mannich addition pathway. B-‐amino carbonyls were synthesized from a variety of substituted nitrones. Bulky and cyclic silyl enol ethers were also found to be reactive, the products of which were isolated in good to excellent yields.
Congdon, Elizabeth A., "Calcium (II) catalyzed nitrone additions" (2016). Honors Theses. 945.