Date of Award
2016
Document Type
Thesis
Degree Name
Bachelor of Science
Department
Biochemistry & Molecular Biol.
First Advisor
Dr. Kristine A. Nolin
Abstract
Calcium(II) complexes have be shown to be successful catalysts for nitrone reactions. The addition of n-‐methyl and n-‐phenyl nitrones to donor-‐acceptor cyclopropanes was achieved with calcium triflate (Ca(OTf). Differentially substituted tetrahydro-‐1,2-‐oxazines were synthesized in good to excellent yields. Calcium triflate was also found to catalyze the addition of silyl enol ethers to n-‐phenyl nitrones along the Mukaiyama-‐Mannich addition pathway. B-‐amino carbonyls were synthesized from a variety of substituted nitrones. Bulky and cyclic silyl enol ethers were also found to be reactive, the products of which were isolated in good to excellent yields.
Recommended Citation
Congdon, Elizabeth A., "Calcium (II) catalyzed nitrone additions" (2016). Honors Theses. 945.
https://scholarship.richmond.edu/honors-theses/945