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Date of Award


Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science



First Advisor

Dr. Valerie Kish


Forty-four percent of all cancers of the central nervous system are malignant gliomas, and of these, at least 23% are glioblastoma multifonne (GBM). Different GBM cell lines have varying p53 gene status and produce varying amounts of proteins. One of the most significant proteins produced is matrix metalloproteinase 2 (MMP-2), which is associated with degradation, of the extracellular matrix (ECM). This allows tumor cells to move throughout the brain. The purpose of these experiments was to determine how MMP-2 activation was altered in the presence of Epidermal Growth Factor (EGF) and epigallocatechin gallate (EGCG) within U87 (wild type for p53) and T98 (mutant for p53) cancer cell lines. Data obtained suggested that U87 cells produced dose-dependent decreases in active MMP-2 in the presence of EGF, as well as showing a clear decrease in activation with EGCG treatment. The T98 cell line showed a slight decrease in activation when treated with EGCG but showed no change with EGF treatment.