Off-campus University of Richmond users: To download campus access theses, please use the following link to log in to our proxy server with your university username and password.
Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Dr. John Gupton
Dr. Wade Downey
For some time now, our research group has pursued an interest in the synthesis of the pyrrole containing natural antibioics of the Pyrrolomycin series that are produced from the bacteria Actinosporangium vitaminophilun. The initial step of the synthetic approach is usually comprised of a reductive amination reaction. The substituted amines produced from this reaction are reacted with a 2-chlorovinadmidinium salt to form 2,4- disubstituted pyrroles. The respective pyrroles were subjected to various reaction conditions in hopes of producing precursors for a new synthetic pathway to F-series Pyrrolomycins, which have been shown to have strong biological activity.
Ruszczyk, Morgan, "A combination strategy for the preparation of pyrrolomycin type alkaloids" (2007). Honors Theses. 195.