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Date of Award

Spring 2007

Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science



First Advisor

Dr. John Gupton

Second Advisor

Dr. Wade Downey


For some time now, our research group has pursued an interest in the synthesis of the pyrrole containing natural antibioics of the Pyrrolomycin series that are produced from the bacteria Actinosporangium vitaminophilun. The initial step of the synthetic approach is usually comprised of a reductive amination reaction. The substituted amines produced from this reaction are reacted with a 2-chlorovinadmidinium salt to form 2,4- disubstituted pyrroles. The respective pyrroles were subjected to various reaction conditions in hopes of producing precursors for a new synthetic pathway to F-series Pyrrolomycins, which have been shown to have strong biological activity.