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Date of Award
Spring 2007
Document Type
Restricted Thesis: Campus only access
Degree Name
Bachelor of Science
Department
Chemistry
First Advisor
Dr. John Gupton
Second Advisor
Dr. Wade Downey
Abstract
For some time now, our research group has pursued an interest in the synthesis of the pyrrole containing natural antibioics of the Pyrrolomycin series that are produced from the bacteria Actinosporangium vitaminophilun. The initial step of the synthetic approach is usually comprised of a reductive amination reaction. The substituted amines produced from this reaction are reacted with a 2-chlorovinadmidinium salt to form 2,4- disubstituted pyrroles. The respective pyrroles were subjected to various reaction conditions in hopes of producing precursors for a new synthetic pathway to F-series Pyrrolomycins, which have been shown to have strong biological activity.
Recommended Citation
Ruszczyk, Morgan, "A combination strategy for the preparation of pyrrolomycin type alkaloids" (2007). Honors Theses. 195.
https://scholarship.richmond.edu/honors-theses/195