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Date of Award
2026
Document Type
Restricted Thesis: Campus only access
Degree Name
Bachelor of Science
Department
Biochemistry & Molecular Biol.
First Advisor
Dr. Chris Shugrue
Abstract
This work describes the development of a strategy to synthesize cyclic peptides and selectively convert them into their linear forms for analysis. Using solid-phase peptide synthesis, peptides were cyclized via intramolecular reductive amination incorporating a secondary amino alcohol cleavable linker, and subsequently linearized through sodium periodate oxidation.
Recommended Citation
Stuart, Nancy, "Synthesis and Oxidative Linearization of Cyclic Peptides for Therapeutic Identification" (2026). Honors Theses. 1949.
https://scholarship.richmond.edu/honors-theses/1949