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Date of Award


Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science



First Advisor

Dr. Emma Goldman

Second Advisor

Dr. Raymond Downey


A library of twelve polysubstituted pyrroles were synthesized using continuous flow methodology. Each step of multi-step process was optimized by varying residence time, temperature, and concentration conditions in order to produce greater than 90% conversions and isolated yields. Residence time (30, 60, and 90 minutes) and temperature (135˚C, 140˚C, and 145˚C) were varied independently showing that both percent yield and conversion are increased by longer residence times and higher temperatures. Sarcosine ethyl ester and glycine methyl ester were used in the final ring closing step to yield either the N-methyl or N-H pyrroles, respectively. It was found that using Hunig’s base with the glycine methyl ester HCl or the sarcosine ethyl ester HCl improves the ring closure step, producing better yields and allowing use of a lower residence time in the former reagent.

Available for download on Saturday, May 07, 3025