Off-campus University of Richmond users: To download campus access theses, please use the following link to log in to our proxy server with your university username and password.
Effects of a novel microtube depolymerizer on pro-inflammatory signaling in RAW264.7 macrophages
Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Biochemistry & Molecular Biol.
Our laboratory explores the therapeutic potential of a class of poly-substituted pyrrole microtubule depolymerizers. Recent work from our laboratory has demonstrated the anti-inflammatory effects of the NT-7-16 compound on the NF-κB signaling pathway, a pathway that produces pro-inflammatory cytokines central to the inflammatory response. Here we explore a potentially more potent stereoisomer mix of an NT analogue, NT-7-45. We expand the scope of our previous work to include another important pro-inflammatory pathway, the interferon pathway. Our results demonstrate a decrease in the production of the antiviral and pro-inflammatory cytokineinterferon-beta (IFN-β) upon exposure to NT-7-45.
Brown, Madeline, "Effects of a novel microtube depolymerizer on pro-inflammatory signaling in RAW264.7 macrophages" (2019). Honors Theses. 1390.