Off-campus University of Richmond users: To download campus access theses, please use the following link to log in to our proxy server with your university username and password.

Date of Award


Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science


Biochemistry & Molecular Biol.


Our laboratory explores the therapeutic potential of a class of poly-substituted pyrrole microtubule depolymerizers. Recent work from our laboratory has demonstrated the anti-inflammatory effects of the NT-7-16 compound on the NF-κB signaling pathway, a pathway that produces pro-inflammatory cytokines central to the inflammatory response. Here we explore a potentially more potent stereoisomer mix of an NT analogue, NT-7-45. We expand the scope of our previous work to include another important pro-inflammatory pathway, the interferon pathway. Our results demonstrate a decrease in the production of the antiviral and pro-inflammatory cytokineinterferon-beta (IFN-β) upon exposure to NT-7-45.