Date of Award
2014
Document Type
Thesis
Degree Name
Bachelor of Science
Department
Biochemistry & Molecular Biol.
Abstract
In protein science the relationship between protein dynamics and catalytic activity are the subject of considerable contemporary interest. Although protein motions are frequently observed during ligand binding and release steps, the contribution of protein motions to the catalysis of bond making/breaking processes is more difficult to probe and verify. Currently, the field of protein science is trying to uncover the deeper role that dynamics plays in the catalytic activity and allosteric regulation of proteins and to better understand how to more effectively and efficiently target proteins in cancer therapeutics and other metabolic pathways.
Recommended Citation
Meeham, Cristina Adelia, "Do the inter-nucleotide domain loops act as an entropic sink in the catalytic activity of 3-phosphoglycerate dehydrogenase (3pGDH)?" (2014). Honors Theses. 1367.
https://scholarship.richmond.edu/honors-theses/1367