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Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Biochemistry & Molecular Biol.
Machado-Joseph disease (MJD) /spinocerebellar ataxia type 3 (SCA3) is an inherited neurodegenerative disease caused by a malfunction of the ataxin-3 protein. It is believed that excessive degree of oxidative stress contributes to the pathogenesis of MJD disease. To determine the role of reactive oxygen species (ROS) in disease pathology, we are using a transgenic Drosophila melanogaster model in which they were fed paraquat with and without SOD2 antioxidant overexpression.
Wang, Yibo, "Do reactive oxygen species contribute to neurodegeneration in drosophila model in Machado Joseph disease" (2018). Honors Theses. 1312.