Off-campus University of Richmond users: To download campus access theses, please use the following link to log in to our proxy server with your university username and password.

Author

Yibo Wang

Date of Award

2018

Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science

Department

Biochemistry & Molecular Biol.

Abstract

Machado-Joseph disease (MJD) /spinocerebellar ataxia type 3 (SCA3) is an inherited neurodegenerative disease caused by a malfunction of the ataxin-3 protein. It is believed that excessive degree of oxidative stress contributes to the pathogenesis of MJD disease. To determine the role of reactive oxygen species (ROS) in disease pathology, we are using a transgenic Drosophila melanogaster model in which they were fed paraquat with and without SOD2 antioxidant overexpression.

Share

COinS