Date of Award

Spring 2011

Document Type

Thesis

Degree Name

Bachelor of Science

Department

Chemistry

First Advisor

Dr. John Gupton

Abstract

This research would not have been possible without the extraordinary guidance of Dr. John Gupton who I like to think of as the brains behind the operation. In addition, Dr. Nakul Telang, a postdoctoral fellow in Dr. Gupton’s research lab, has provided great support, assistance and humor throughout my undergraduate research career. The other student members of the lab that I would like to recognize for their support and contribution to this project are Ben Giglio, James Eaton, Peter Barelli, Mona Hovaizi, Kayleigh Hall, Scott Welden, Kara Finzel. We also thank the National Institutes of Health (grant no. R15‐CA67236) for support of this research. We are exceedingly grateful to Mr. Dave Patteson formerly of Biotage Inc. for the generous donation of a Horizon HFC and SP‐1 flash chromatography systems, which was used in the majority of sample purifications. Recent grants from the MRI program of the National Science Foundation for the purchase of a 500 MHz NMR spectrometer (CHE‐0116492) and an electrospray mass spectrometer (CHE‐0320669) are also gratefully acknowledged. We thank the Arnold and Mabel Beckman Foundation for fellowship support to Benjamin C. Giglio and Professors Wade Downey and Kristine Nolin for making helpful suggestions as to the nature of this manuscript.

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