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Author

Hyejin Park

Date of Award

2017

Document Type

Restricted Thesis: Campus only access

First Advisor

Dr. Julie Pollock

Abstract

The role of estrogen receptors (ER) in development of breast cancer has been studied intensively. Selective estrogen receptor modulators (SERMs) and anti-estrogens have been clinically used to treat estrogen receptor positive breast cancer. Building upon this idea, this paper introduces development of boronic ester ligands as selective pro-drugs for breast cancer cells. The first goal of this study was to synthesize and characterize boronic ester estrogens. The results show successful conversion of inactive ligand into active ligand in the environment with high level of hydrogen peroxide. Moreover, this paper reports synthesis of diarylpropionitrile (DPN) and various boronic ester DPN as selective agonist for ERâ.

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