Off-campus University of Richmond users: To download campus access theses, please use the following link to log in to our proxy server with your university username and password.

Date of Award


Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science


Biochemistry & Molecular Biol.

First Advisor

Dr. Krista Stenger


NT-07-16 is a brominated, polysubstituted pyrrole with known microtubule- depolymerizing and antitumor activity. This study focused on the compound’s effects on the pro- inflammatory NF-κB signaling pathway as a potential anti-inflammatory agent. Changes in pro- inflammatory cytokine production and expression after NT-07-16 exposure and LPS activation were quantified. The results have shown that NT-07-16 decreases production of the pro- inflammatory cytokines TNF-α and IL-6 and downregulates expression of the corresponding pro- inflammatory genes TNFA, IL6, and IL1. The anti-inflammatory effects exhibited by NT-07-16 further support the possibility for NT-07-16 to be used in the clinical setting.