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Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Biochemistry & Molecular Biol.
Dr. Krista Stenger
NT-07-16 is a brominated, polysubstituted pyrrole with known microtubule- depolymerizing and antitumor activity. This study focused on the compound’s effects on the pro- inflammatory NF-κB signaling pathway as a potential anti-inflammatory agent. Changes in pro- inflammatory cytokine production and expression after NT-07-16 exposure and LPS activation were quantified. The results have shown that NT-07-16 decreases production of the pro- inflammatory cytokines TNF-α and IL-6 and downregulates expression of the corresponding pro- inflammatory genes TNFA, IL6, and IL1. The anti-inflammatory effects exhibited by NT-07-16 further support the possibility for NT-07-16 to be used in the clinical setting.
Li, Elizabeth C., "Anti-inflammatory effects of an improved pyrrole-based microtubule-depolymerizing compound on RAW264.7 macrophages" (2017). Honors Theses. 992.