Date of Award
Bachelor of Science
Lycogarubln C is a member of an interesting family of marine natural products, which contains two indole groups appended to a pyrrole scaffold at the 3 and 4 positions. Such compounds are proposed to be biosynthetically related to the important antitumor agent, Staurosporine. Recent work in our lab involving the use of Suzuki cross-coupling reactions of an ortho activated bromoformylpyrrole ester has provided key intermediates for the synthesis of pyrrole natural products and pyrolle-based analogues.
Patteson, Jon, "The application of formyl group activation of brompyrrole esters to a formal synthesis of lycogarubin C" (2015). Honors Theses. 958.