Date of Award


Document Type


Degree Name

Bachelor of Science


Biochemistry & Molecular Biol.

First Advisor

Dr. John Gupton


Many biologically interesting compounds have been isolated from marine natural products, many of which contain characteristic pyrroles. Compounds such as polycitones, storniamides, ningalins, and lamellarins have been of particular interest for synthesis due to their vast pharmaceutical potential including the ability to fight tumors as well as induce cytolysis of drug resistant cancer cell lines. Previous studies on the synthesis of Lamellarin G trimethyl ether by the Gupton Group have relied upon vinylogous amide derivatives as building blocks.2 A new pathway utilizing a formylated pyrrole ring provides an interesting method for the synthesis of Lamellarin G trimethyl ether. Regioselective Suzuki cross-coupling of the pyrrole leads to relay synthesis of the marine alkaloid yet the possibilities of generated compounds from the activated pyrrole building block are numerous.