Date of Award
Bachelor of Science
Biochemistry & Molecular Biol.
Dr. C. Wade Downey
One-pot reactions were studied in order to develop procedures for the formation of important carbon-carbon and carbon-nitrogen bonds that are easily reproducible. In the presence of trimethylsilyl triflouromethanesulfonate (TMSOTf), Mukaiyama-aldol and aldol-like reactions occur in one-pot due to TMSOTf acting as a Lewis acid and silylating agent. A variety of reactions, including methoxyalkylation, were performed to form carbon-nitrogen bonds. Here, research involving TMSOTf-mediated additions to acetals, nitrones, and aminals will be discussed.
Safran, Chelsea, "Trimethylsilyl trifluoromethanesulfonate-mediated additions to acetals, nitrones, and aminals" (2013). Honors Theses. 71.