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Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Dr. Jeff Elhai
Many bacteria have evolved a defense mechanism against foreign DNA: restriction enzymes (Bickle and Kruger, 1993). These proteins patrol the cell and degrade intruding DNA, thus protecting the cell from outside DNA. Restriction enzymes recognize specific sequences in DNA (-AATCG- for example) called restriction sites. Obviously, the bacteria must protect their own DNA from their restriction enzymes, and a common defense would be to attach a molecule (such as a methyl group, -CH3) to the DNA so the enzyme cannot fit around its restriction site. What if an invading strand of DNA has this same protection?
Magliaro, Brian C., "Resistance of the T4 virus to restriction enzymes in E. Coli ; utilization or an evolutionary missing link" (1998). Honors Theses. 563.