Off-campus University of Richmond users: To download campus access theses, please use the following link to log in to our proxy server with your university username and password.

Date of Award


Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science



First Advisor

Dr. Valerie Kish


Chlamydomonas reinhardtii is a single celled alga with two microtubule-based flagella. In vivo, these flagella are retracted into the cell prior to mitosis and are then regenerated in the new cells. Experimentally, the flagella can be amputated by lowering the pH of the cell culture, thus making it possible to study flagellar regeneration in the laboratory. Melatonin is a hormone which is known to affect tubulin polymerization in the microtubules of certain cell types. Based on past findings, we hypothesize that in Chlamydomonas, high concentrations of melatonin will inhibit flagellar regeneration while low concentrations of melatonin will enhance this process. We have found instead that high melatonin levels enhance flagellar regeneration while low levels impede it. Since melatonin is known to bind to the calcium-calmodulin complex, we are investigating the relationship between calcium and melatonin in calmodulin binding as a means of explaining melatonin's observed effects on flagellar regeneration.