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Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Dr. Krista Fischer-Stenger
Previous studies have shown that norepinephrine (NE) can be synthesized, secreted; and taken up by macrophages. This study uses the murine macrophage RAW264.7 cell line as a model to study the effects of NE treatment on macrophage cytolytic activity. Lipopolysaccharide (LPS) is shown to induce macrophage cytolytic activity'in vitro, however results for NE treatment with and without LPS activation of macrophages were inconclusive. These results suggest that NE alters macrophage cytolytic activity, but further studies will need to be done in order to understand the mechanism responsible for these effects.
Drake, Lindsey, "The effect of norepinephrine on macrophage cytolytic activity" (2005). Honors Theses. 384.