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Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Dr. Valerie M. Kish
Gliomas, cancers that originate from the glial support cells of the brain, are the most common type of intracranial tumors in humans (Russell and Rubenstein, 1989). Gliomas are highly invasive and are characterized by the degradation and remodification of the extracellular matrix (ECM). High-grade gliomas are unique in their ability to invade surrounding normal brain tissue cells and proliferate. As a result, the complete surgical removal of infiltrated cells is close to impossible to accomplish successfully. The subsequent poor prognosis and low survival rate of glioma patients necessitates the need for a greater understanding of the mechanisms that underlie invasive gliomas. An understanding of these mechanisms could lead to the development of non-surgical therapies that might be useful in the treatment of these deadly cancers.
Goreczny, John, "The effect of epidermal growth factor on MMP-production and activation in human glioblastoma multiforme cell lines U87 and LNZ" (2004). Honors Theses. 381.