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Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Dr. Valerie Kish
Human glioblastoma multiforme (GBM) is a grade IV astrocytic tumor which happens to be the most common type of brain tumor, affecting more that 60% of people diagnosed with brain cancer. GBM is the most invasive type of brain cancer known. When the support cells of the brain, glial cells, become cancerous, they spread throughout normal brain tissue and even through cerebrospinal fluid pathways. People of all ages may be afflicted with this disease and, currently, there is no cure. These highly infiltrative cells leave patients with a poor prognosis. Typically this cancer causes death within one year of diagnosis. Modern cancer therapies such as chemotherapy, radiation, and surgical resection have not made progress in over twenty five years to extend life expectancy (Bruce, 2005).
Gabriel, Ryan, "The effect of RNAi on Hsp-27 and MMP-2 secretion in U87glioma cells" (2007). Honors Theses. 191.