Date of Award


Document Type


Degree Name

Bachelor of Science


Biochemistry & Molecular Biol.

First Advisor

C. Wade Downey


When ketones are treated with trimethylsilyl trifluoromethanesulfonate (TMSOTf) and 2,6- lutidine, they react with N-benzyl nitrones to provide diverse compounds, such as beta- aminoketones and 2,3-dihydroisoxazoles. When the reaction mixture is heated to reflux in methylene chloride, the 1,3-addition product is observed. However, when the product is deprotected using TBAF and treated with methanesulfonyl chloride, a 2,3-dihydroisoxazole can be formed. Results under a variety of conditions, leading to different mixtures of products, are presented.

Available for download on Monday, May 17, 2027