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Date of Award
4-30-2021
Document Type
Restricted Thesis: Campus only access
Degree Name
Bachelor of Science
Department
Biochemistry & Molecular Biol.
First Advisor
Julie A. Pollock
Abstract
Breast cancer is the most common type of cancer among women. Specifically, in the United States, 12.5% of women are diagnosed with breast cancer and 1/35 individuals face the risk of dying from breast cancer (Ataollahi et al., 2015). Therefore, there is great significance and importance to find a solution to slow down or inhibit the progression of breast cancer. One specific protein, modulator of ERBB2-driven cell motility 1 (MEMO1), has been found to play a key role in breast cancer development and progression due to its interaction and binding with another protein, the tyrosine kinase erythroblastic oncogene B 2 (ERBB2) (Marone et al., 2004). In this research, peptide mimics of ERBB2 were synthesized and their ability to modulate the protein-protein interaction with MEMO1 and the resulting signaling cascade which contributes to breast cancer progression was investigated. In the future, this research may demonstrate that peptides can serve as phosphotyrosine mimics and can be utilized to regulate tyrosine phosphorylation in other protein-protein interactions.
Recommended Citation
Chongsaritsinsuk, Joann, "Synthesis of modulators of the MEMO1 protein-protein interface" (2021). Honors Theses. 1587.
https://scholarship.richmond.edu/honors-theses/1587