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Date of Award
2020
Document Type
Restricted Thesis: Campus only access
Degree Name
Bachelor of Science
Department
Chemistry
First Advisor
Dr. Emma Goldman
Second Advisor
Dr. Raymond Dominey
Abstract
Polysubstituted Pyrroles hold an important position as bioactive compounds. Due to their pyrrole backbone, they can hold many different combinations of substituents, thus allowing them to have activity against a wide range of illnesses and disorders. In this work, synthetic batch chemistry methods for these pyrroles, published by Dr. John Gupton, were optimized using flow chemistry. A continuous flow method resulted in a significant decrease in reaction time as well as a decrease in the number of extraction, isolation and purification steps, while maintaining high isolated yield. With a functional continuous flow method, a library of Polysubstituted Pyrroles can be synthesized more efficiently than via batch methods.
Recommended Citation
Perez Mandry, Carlos J., "A Flow Chemistry Implementation of the “Gupton Vinylogous Amide Chemistry” for High-yield, Regiospecific Synthesis of Unsymmetrical Polysubstituted Pyrroles" (2020). Honors Theses. 1503.
https://scholarship.richmond.edu/honors-theses/1503