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Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Dr. Emma Goldman
Dr. Raymond Dominey
Polysubstituted Pyrroles hold an important position as bioactive compounds. Due to their pyrrole backbone, they can hold many different combinations of substituents, thus allowing them to have activity against a wide range of illnesses and disorders. In this work, synthetic batch chemistry methods for these pyrroles, published by Dr. John Gupton, were optimized using flow chemistry. A continuous flow method resulted in a significant decrease in reaction time as well as a decrease in the number of extraction, isolation and purification steps, while maintaining high isolated yield. With a functional continuous flow method, a library of Polysubstituted Pyrroles can be synthesized more efficiently than via batch methods.
Perez Mandry, Carlos J., "A Flow Chemistry Implementation of the “Gupton Vinylogous Amide Chemistry” for High-yield, Regiospecific Synthesis of Unsymmetrical Polysubstituted Pyrroles" (2020). Honors Theses. 1503.