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Date of Award

2018

Document Type

Restricted Thesis: Campus only access

Abstract

Interest in the promutagenic lesion 8-oxo-2'-deoxyguanosine (OdG) arises from its ability to form quite easily via the reaction between reactive oxygen species and 2'-deoxyguanosine. The prevalence of reactive oxygen species in the body should be noted, as the literature states that humans have roughly 10,000 to 20,000 free radicals attacking body cells daily. Genetic DNA is especially vulnerable to the adverse effects of reactive oxygen species because these species can react with DNA bases or the DNA backbone. OdG is able to successfully base pair with both 2'-deoxycytidine (dC), which is the norm, or with 2'-deoxyadenosine (dA), which causes dG to dT (2'-deoxythymidine) transversions. Through understanding the mutagenicity of OdG, we may be able to better comprehend senescence and the origin of diseases such as arthritis, lupus, and cancer that are associated with reactive oxygen species.

Available for download on Tuesday, November 12, 2019

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