Author

Sean Foster

Date of Award

2006

Document Type

Thesis

Degree Name

Bachelor of Science

Department

Biology

First Advisor

Linda Boland, Ph.D.

Abstract

Due to the large variety of Kchannel families implicated in cancer cell proliferation, it is desirable to develop techniques capable of quickly and reliably screening a variety of potential channels for a role in proliferation. While there are many established cell counting procedures, the time-consuming nature of such protocols limits their usefulness in broadly identifying particular channels in uncharacterized cell lines. For this reason, a primary goal of the present research was the development of techniques capable of implicating particular ion channels in proliferation with both qualitative and quantitative data. Once this goal was accomplished, the project sought to conduct preliminary investigations into the role of potassium channels in PEG cell proliferation using the developed techniques.

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