Declining hepatitis A seroprevalence: a global review and analysis
Document Type
Article
DOI
10.1017/S0950268804002857
Publication Date
11-16-2004
Abstract
Hepatitis A virus (HAV) is spread by faecal–oral contact or ingestion of contaminated food or water. Lifelong immunity is conferred by infection or vaccination, so anti-HAV seroprevalence studies can be used to indicate which populations are susceptible to infection. Seroprevalence rates are highly correlated with socioeconomic status and access to clean water and sanitation. Increasing household income, education, water quality and quantity, sanitation, and hygiene leads to decreases in HAV prevalence. Japan, Australia, New Zealand, Canada, the United States, and most European nations have low anti-HAV rates. Although anti-HAV rates remain high in most Latin American, Asian, and Middle Eastern nations, average seroprevalence rates are declining. Surveys from Africa generally indicate no significant decline in anti-HAV rates. Because the severity of illness increases with age, populations with a high proportion of susceptible adults should consider targeted vaccination programmes.
Publisher Statement
Copyright © 2004, Cambridge University Press.
Recommended Citation
Jacobsen KH, Koopman JS. Declining hepatitis A seroprevalence: a global review and analysis. Epidemiology & Infection. 2004 Dec; 132(6): 1005–1022.