Method for identification of origins of replication and genes regulated by DnaA in bacteria

Author

Olga G. Troyanskaya, University of Richmond

Date of Award

1999

Document Type

Thesis

Degree Name

Bachelor of Science

Department

Biology

Abstract

The study is focused on developing computer programs to identify origin of DNA replication based on analysis of total bacterial genomes, scoring regions for number of DnaA binding sites, AT content, DNA adenine methylase boxes, and integration host factors binding sites. The programs were tested on cyanobacterium Synechocystis, and several potential origins were identified. However, no one definite region could be located. Currently, software is being developed to analyze common motifs around the origins of all bacteria with known origins. Genes whose transcription could be regulated by DnaA were identified by searching for DnaA boxes preceding promoter regions.

Recommended Citation

Troyanskaya, Olga G., "Method for identification of origins of replication and genes regulated by DnaA in bacteria" (1999). Honors Theses. 966.
https://scholarship.richmond.edu/honors-theses/966