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Date of Award
2024
Document Type
Restricted Thesis: Campus only access
Degree Name
Bachelor of Science
Department
Biochemistry & Molecular Biol.
First Advisor
Dr. C. Wade Downey
Second Advisor
Dr. Christopher Shugrue
Abstract
Modifying indoles, benzofurans, and benzothiophenes is of high importance in the scientific field. Indoles, benzofurans, and benzothiophenes have a diverse range of chemical activity, involved in many biologically-related interactions, and are found in many natural products. Therefore, being able to modify the substituents of indoles, benzofurans, and benzothiophenes in a controlled and efficient manner is pivotal to the innovations of the scientific field. Specifically, in the work described below, we developed Friedel–Crafts addition and alkylation on the 3-position of the indole with nitrones, and secondary acetates and tertiary alcohols, respectively. We also developed Friedel–Crafts alkylation of benzofurans at the 2-position and benzothiophenes at the 3-position with secondary acetates and tertiary alcohols.
Recommended Citation
Xia, Helen, "Friedel–Crafts addition of indoles to nitrones and alkylation of indoles, benzofurans, and benzothiophenes promoted by trimethylsilyl trifluoromethanesulfonate" (2024). Honors Theses. 1734.
https://scholarship.richmond.edu/honors-theses/1734