Blood clots form rapidly in the event of vascular injury, to prevent blood loss. They may also form in undesired places, causing heart attacks, strokes, and other diseases. Blood clots can rupture, and fragments of the clotmay lodge in distal blood vessels, causing, for example, ischemic strokes or embolisms. Thus, there has been great interest in understanding the mechanical behavior and failure mechanisms of blood clots and their constituents. To develop a mechanically realistic model of a blood clot, knowledge of the mechanical properties of its constituents is required. The major structural component providing mechanical strength to the clot is a mesh of fibrin fibers. Principally, three pieces of information are needed to develop realistic (fibrin fiber) network models: (i) the architecture of the network; (ii) the properties of the single fibers; and (iii) the properties of the fiber branchpoints.

Document Type

Post-print Article

Publication Date



Alternate Author Names: C.R. Carlisle or Christine R. Carlisle

Publisher Statement

Copyright © 2010 International Society on Thrombosis and Haemostasis. Article first published online: 24 FEB 2010. DOI: 10.1111/j.1538-7836.2010.03824.x

The definitive version is available at:

Full citation:

Carlisle, C. R., E. A. Sparks, C. Der Loughian, and M. Guthold. "Strength and Failure of Fibrin Fiber Branch Points." Journal of Thrombosis and Haemostasis 8, no. 5 (May 2010): 1135-138. doi:10.1111/j.1538-7836.2010.03824.x.