Abstract
RNA editing by adenosine deamination gives an organism the ability to alter its protein-coding sequences, resulting in an overall change in protein structure and function. Adenosine deaminases acting on RNA (ADARs) convert specific adenosines (A) into inosines (I) that are interpreted as guanosines (G) by the translational machinery. Coleoid cephalopods (octopus, squid, and cuttlefish), like vertebrates, possess two catalytically active ADAR enzymes, sqADAR1 and sqADAR2, but unlike any other organism, cephalopods recode transcripts by A-to-I RNA editing to an extraordinary extent, particularly in neuronal tissue.
Recommended Citation
Friedman, Kayla; Voss, Gjendine; and Rosenthal, Joshua
(2023)
"Unraveling ADAR expression and RNA editing activity in adult and embryonic tissue in the squid Euprymna berryi,"
Osmosis Magazine: Vol. 2023:
Iss.
2, Article 4.
Available at:
https://scholarship.richmond.edu/osmosis/vol2023/iss2/4
