On his website, University of Utah mathematics professor James Keener poses the question, “Did you know that heart attacks can give you mathematics!?” Indeed, there are a host of important research problems in cardiology that appear ideal for unified attack by mathematicians, clinicians, and biomedical engineers.What follows is a survey of six ongoing Challenge Problems that (i) seem tractable and (ii) draw from a variety of mathematical subdisciplines. We hope that this article will serve as a “call to arms” for mathematicians so that we, as a community, can contribute to an improved understanding of cardiac abnormalities.

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Copyright © 2011 American Mathematical Society. This article first appeared in Notices of the American Mathematical Society 58:4 (2011), 542-549.

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