The human immune response to bacterial pathogens is a remarkably complex process, involving many different cell types, chemical signals, and extensive lines of communication. Mathematical models of this system have become increasingly high-dimensional and complicated, as researchers seek to capture many of the major dynamics. In this paper, we argue that, in some important instances, preference should be given to low-dimensional models of immune response, as opposed to their high-dimensional counterparts. One such model is analyzed and shown to reflect many of the key phenomenological properties of the immune response in humans. Notably, this model includes a single parameter values, may be used to quantify the overall immuno-competence of individual hosts.

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Post-print Article

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Copyright © 2013 Springer US.

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DOI: 10.1007/s11538-013-9854-1

Full Citation:

Caudill, Lester. "A Single-Parameter Model of the Immune Response to Bacterial Invasion." Bulletin of Mathematical Biology 75, no. 9 (2013): 1434-1449. doi:10.1007/s11538-013-9854-1.