Date of Award
Master of Science
Six groups of white labor atory rats were utilized in this experiment. A sham-operated group and an adrenalectomized group were used as controls. Four other groups were adrenalectomized and given replacement therapy of cortisone, deoxycorticosterone acetate, epinephrine, and norepinephrine. All groups were then given injections of toad toxin from the parotid glands of Bufo marinus. Their heart and breathing rates were recorded for 60 minutes.
All of the untreated adrenalectomized rats showed altered heart and breathing rates and were killed by the toxin. Cortisone and nor epinephrine aided the adrenalectomiz ed rats to survive. but cortisone was the more effective of the two.
Green, Mark A., "The role of the adrenal gland in the survival of white rats subjected to the parotid toxin of the toad, Bufo marinus" (1972). Master's Theses. 348.