Date of Award

Summer 1966

Document Type


Degree Name

Master of Science




In August, 1965 Andrew Bachmann presented a thesis based on the fact that indole was selectively absorbed in the cancer tissue. This paper is similar in that indole is used as the means of transport to concentrate the alkylating agents in the tumor. The alkylating agents presented in this paper are ep­oxides and methane sulfonates.

The historical portion of this paper is designed to show the value of epoxides and methane sulfonates in chemotherapy. The experimental portion is composed of the synthesis of these com.pounds, related intermediates, and a new color test which is a potential method for the detection of indole in a tumor.

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