Date of Award
Master of Science
This thesis concerns the use of ethyl N-substituted oxamates and ethyl N, N-di-substituted oxamates as intermediates in the synthesis of large molecules.
Richardson et al. (1) showed that ethyl N-aryloxamates were effective in differentiating between primary and secondary alkyl amines.
This thesis makes use of such differentiating ability in order to obtain preferential reaction on series of compounds, each compound containing both primary and secondary amino groups.
Further, the oxamates have been modified in an attempt to find compounds with greater differentiating ability than those used by Richardson et al., (1).
The use of oxamates describes herein offer a synthetic route to extensive series of potentially active pharmaceutical compounds.
Tenney, Linwood Powers, "Oxamates as intermediates" (1962). Master's Theses. 1343.