Production of 2-alkyl- or cycloalkyl-4-methyl-6- hydroxypyrimidines by first neutralizing an alkyl imidate ester hydrochloride with a base in the presence of a water-immiscible solvent for the alkyl imidate ester to be freed thereby; condensing the alkyl imidate ester with diketene to form an oxazinone intermediate, which is then reacted in organic solution with gaseous ammonia and recovering the desired substituted 6-hydroxypyrimidine.
Copyright © 1979 United States Patent and Trademark Office
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Blackwell, Joseph T., III, John T. Gupton, Teruko U. Miyazaki, James B. Nabors, and Joseph R. Pociask. A Process for the Production of 2-Alkyl or 2-Cycloalkyl-4-methyl-6-hydroxypyrimidines. US Patent 4163848, filed August 8, 1978, and issued August 7, 1979.