Production of 2-alkyl or 2-cycloalkyl-4-methyl-6-hydroxy pyrimidines by sequentially reacting without isolation of any intermediates in an organic solvent (1) diketene and ammonia to produce .beta.-aminocrotonamide and (2) .beta.-aminocrotonamide, after water removal therefrom, a lower alkanoic or cycloalkanoic acid ester and an alkali metal alkoxide.
Copyright © 1977 United States Patent and Trademark Office
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Blackwell, J. Thomas, John T. Gupton, and Jim B. Nabors. Process for the Production of 2-alkyl or 2-cycloalkyl-4-methyl-6-hydroxypyrimidines. US Patent 4,052,397, filed November 22, 1976, and issued October 4, 1977.