Production of 2-alkyl or 2-cycloalkyl-4-methyl-6-hydroxy pyrimidines by first reacting diketene and lower alkanoic or cycloalkanoic acid amides in the presence of catalytic amounts of Lewis bases or Lewis or Bronsted acids, followed by treating the N-acetoacetyl (lower) alkanoic or cycloalkanoic acid amide intermediates with ammonia in the presence of acid catalysts.
Copyright © 1977 United States Patent and Trademark Office.
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Gupton, John T., Alex M. Jelenevsky, Teruko U. Miyazaki, and Harries E. Petree. Process for the Production of 2-alkyl or 2-cycloalkyl-4-methyl-6-hydroxypyrimidines. US Patent 4,018,771, filed August 23, 1976, and issued April 19, 1977.