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Author

Lindsey Drake

Date of Award

Spring 2005

Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science

Department

Biology

First Advisor

Dr. Krista Fischer-Stenger

Abstract

Previous studies have shown that norepinephrine (NE) can be synthesized, secreted; and taken up by macrophages. This study uses the murine macrophage RAW264.7 cell line as a model to study the effects of NE treatment on macrophage cytolytic activity. Lipopolysaccharide (LPS) is shown to induce macrophage cytolytic activity'in vitro, however results for NE treatment with and without LPS activation of macrophages were inconclusive. These results suggest that NE alters macrophage cytolytic activity, but further studies will need to be done in order to understand the mechanism responsible for these effects.

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