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Author

Katie Griffin

Date of Award

4-2003

Document Type

Restricted Thesis: Campus only access

Degree Name

Bachelor of Science

Department

Biology

First Advisor

Dr. Clough

Abstract

Heterocyclic compounds have been commonly used as anti-fungal, anti-microbial, and anti-tumor drugs due to the biological activity associated with these products. There are many naturally occurring compounds that contain multiple rings, one example being Nigalin B, which is known to have anti-tumor activity. Dr. Gupton and his research team have successfully synthesized this compound through a series of steps. One of the early precursors, three carbon synthons known as 3-chloroenals, was of interest because ofthe possibility to expand the hydrocarbon chain affording a five carbon synthon. This compound could then be used to synthesize a variety of other compounds with select regiochemistry, such as paracotoin (Figure 1) or various 2-pyridones known to have antibacterial activity (Li et al. 2000, Barar 1998, and Meulbroek et al. 1996) or antitumor activity (Cocco et al. 2000).

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