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Date of Award
Restricted Thesis: Campus only access
Bachelor of Science
Dr. Valerie M. Kish
Glioblastoma multiforme is the most aggressive form of primary brain cancer in adults. It is almost always fatal, with a five-year survival rate of less than 5% (Holland, 2000). It invades the brain tissue at an alarming rate and is almost impossible to remove by surgery. Often by the time a diagnosis has been made, the tumor has progressed so far into the brain that radiation and chemotherapy are of no use, and it becomes fatal within a short period of time. The tumor cells spread in the brain by degrading the extracellular matrix that holds brain cells together, and thus creating an open pathway through which the tumor can migrate. A family of enzymes, called matrix metalloproteinases (MMPs) is responsible for this degradation. They are involved in both the invasion and proliferation of tumors. Gliomas express elevated levels ofMMPs (Kunapuli et al., 2004) and their role clearing a path in the extracellular matrix for the spread of cancer tumors is being investigated for their use in cancer treatment possibilities.
Clark, Emily, "Regulation of membrane type-l matrix metalloproteinases by Tyrosine phosphorylation in human glioma cells" (2004). Honors Theses. 364.